UBC Manila is located in Nicanor Reyes Sr. St. (formerly Morayta), in the University Belt in Sampaloc, Manila. It is accessible by public transportation on these routes:

1. From Quezon City : take any jeep or FX bound for Quiapo via España.
2. From Mandaluyong, Pasig, Cainta or Antipolo : Take a G-Liner bus, jeep, or FX bound for Quiapo. Alight at Mendiola and transfer to a jeep bound for Divisoria.
3. From Pasay and Baclaran: Take a jeep or FX bound for Quezon City (Cubao; Project 2, 3; Fairview) via Espana.
4. From Divisoria: Take a jeep or FX bound for San Juan or Cubao.
5. One may also take the LRT (Baclaran-Monumento) and alight at Doroteo Jose station. From there, take a Morayta-Gastambide jeep to get off in front of UBC.
6. One may also take the LRT 2 (Santolan-Recto) and alight at Recto Station. From there, take a Morayta-Gastambide jeep to get off in front of UBC.